Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even Early after Telomerase Inactivation (ETI), yeast mother cells show transient DNA Damage Response (DDR) episodes, stochastically altered cell cycle dynamics, a...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Xie, Zhengwei, Jay, Kyle A., Smith, Dana L., Zhang, Yi, Liu, Zairan, Zheng, Jiashun, Tian, Ruilin, Li, Hao, Blackburn, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496004/
https://ncbi.nlm.nih.gov/pubmed/25723167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.002
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