Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even Early after Telomerase Inactivation (ETI), yeast mother cells show transient DNA Damage Response (DDR) episodes, stochastically altered cell cycle dynamics, a...

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Bibliographic Details
Published in:Cell
Main Authors: Xie, Zhengwei, Jay, Kyle A., Smith, Dana L., Zhang, Yi, Liu, Zairan, Zheng, Jiashun, Tian, Ruilin, Li, Hao, Blackburn, Elizabeth
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496004/
https://ncbi.nlm.nih.gov/pubmed/25723167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.002
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