P2X(7) receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages

The P2X(7) receptor (P2X(7)R) is highly expressed on the macrophage cell surface and activation of infected cells by extracellular ATP has been shown to kill intracellular bacteria and parasites. Furthermore, single nucleotide polymorphisms (SNPs) that decrease receptor function reduce the ability o...

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Main Authors: Lees, Michael P., Fuller, Stephen J., McLeod, Rima, Boulter, Nicola R., Miller, Catherine M., Zakrzewski, Alana M., Mui, Ernest J., Witola, William H., Coyne, Jessica J., Hargrave, Aubrey C., Jamieson, Sarra E., Blackwell, Jenefer M., Wiley, James S., Smith, Nicholas C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931343/
https://ncbi.nlm.nih.gov/pubmed/20488797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000012
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