P2X(7) receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages

The P2X(7) receptor (P2X(7)R) is highly expressed on the macrophage cell surface and activation of infected cells by extracellular ATP has been shown to kill intracellular bacteria and parasites. Furthermore, single nucleotide polymorphisms (SNPs) that decrease receptor function reduce the ability o...

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Autors principals: Lees, Michael P., Fuller, Stephen J., McLeod, Rima, Boulter, Nicola R., Miller, Catherine M., Zakrzewski, Alana M., Mui, Ernest J., Witola, William H., Coyne, Jessica J., Hargrave, Aubrey C., Jamieson, Sarra E., Blackwell, Jenefer M., Wiley, James S., Smith, Nicholas C.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931343/
https://ncbi.nlm.nih.gov/pubmed/20488797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000012
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