P2X(7) receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages

The P2X(7) receptor (P2X(7)R) is highly expressed on the macrophage cell surface and activation of infected cells by extracellular ATP has been shown to kill intracellular bacteria and parasites. Furthermore, single nucleotide polymorphisms (SNPs) that decrease receptor function reduce the ability o...

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Detalhes bibliográficos
Main Authors: Lees, Michael P., Fuller, Stephen J., McLeod, Rima, Boulter, Nicola R., Miller, Catherine M., Zakrzewski, Alana M., Mui, Ernest J., Witola, William H., Coyne, Jessica J., Hargrave, Aubrey C., Jamieson, Sarra E., Blackwell, Jenefer M., Wiley, James S., Smith, Nicholas C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931343/
https://ncbi.nlm.nih.gov/pubmed/20488797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000012
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