Involvement of Caveolin in Low K(+)-induced Endocytic Degradation of Cell-surface Human Ether-a-go-go-related Gene (hERG) Channels

Reduction in the rapidly activating delayed rectifier K(+) channel current (I(Kr)) due to either mutations in the human ether-a-go-go-related gene (hERG) or drug block causes inherited or drug-induced long QT syndrome. A reduction in extracellular K(+) concentration ([K(+)](o)) exacerbates long QT s...

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Bibliographische Detailangaben
Hauptverfasser: Massaeli, Hamid, Sun, Tao, Li, Xian, Shallow, Heidi, Wu, Jimmy, Xu, Jianmin, Li, Wentao, Hanson, Christian, Guo, Jun, Zhang, Shetuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930725/
https://ncbi.nlm.nih.gov/pubmed/20605793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.124909
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