PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving PARK2, the gene encoding PARKIN, the E3 ubiquitin ligase whose deficiency is responsible for a form of autosomal recessive juvenile parkinsonism....

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Main Authors: Poulogiannis, George, McIntyre, Rebecca E., Dimitriadi, Maria, Apps, John R., Wilson, Catherine H., Ichimura, Koichi, Luo, Feijun, Cantley, Lewis C., Wyllie, Andrew H., Adams, David J., Arends, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930574/
https://ncbi.nlm.nih.gov/pubmed/20696900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009941107
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