PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving PARK2, the gene encoding PARKIN, the E3 ubiquitin ligase whose deficiency is responsible for a form of autosomal recessive juvenile parkinsonism....

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Hauptverfasser: Poulogiannis, George, McIntyre, Rebecca E., Dimitriadi, Maria, Apps, John R., Wilson, Catherine H., Ichimura, Koichi, Luo, Feijun, Cantley, Lewis C., Wyllie, Andrew H., Adams, David J., Arends, Mark J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930574/
https://ncbi.nlm.nih.gov/pubmed/20696900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009941107
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