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Oxidation enhances myofibrillar protein degradation via calpain and caspase-3

Oxidative stress has been linked to accelerated rates of proteolysis and muscle fiber atrophy during periods of prolonged skeletal muscle inactivity. However, the mechanism(s) that link oxidative stress to muscle protein degradation remain unclear. A potential connection between oxidants and acceler...

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Detalhes bibliográficos
Main Authors: Smuder, Ashley J., Kavazis, Andreas N., Hudson, Matthew B., Nelson, W. Bradley, Powers, Scott K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930052/
https://ncbi.nlm.nih.gov/pubmed/20600829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.06.025
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