Cross-talk between the calpain and caspase-3 proteolytic systems in the diaphragm during prolonged mechanical ventilation

OBJECTIVE: Diaphragmatic weakness, due to both atrophy and contractile dysfunction, is a well-documented response following prolonged mechanical ventilation (MV). Evidence indicates that activation of the proteases calpain and caspase-3 are essential for MV-induced diaphragmatic weakness to occur. W...

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Bibliographic Details
Main Authors: Nelson, W. Bradley, Ashley J., Smuder, Hudson, Matthew B., Talbert, Erin E., Powers, Scott K.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358441/
https://ncbi.nlm.nih.gov/pubmed/22487998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e318246bb5d
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