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Cross-talk between the calpain and caspase-3 proteolytic systems in the diaphragm during prolonged mechanical ventilation
OBJECTIVE: Diaphragmatic weakness, due to both atrophy and contractile dysfunction, is a well-documented response following prolonged mechanical ventilation (MV). Evidence indicates that activation of the proteases calpain and caspase-3 are essential for MV-induced diaphragmatic weakness to occur. W...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358441/ https://ncbi.nlm.nih.gov/pubmed/22487998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e318246bb5d |
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