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CD39/ENTPD1 expression by CD4(+)Foxp3(+) regulatory T cells promotes hepatic metastatic tumor growth in mice

BACKGROUND & AIMS: Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (Treg). Although tumor-infiltrating immune cells include Foxp3(+) Treg, it is not clear whether local...

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Bibliographische Detailangaben
Hauptverfasser: SUN, XIAOFENG, WU, YAN, GAO, WENDA, ENJYOJI, KEIICHI, CSIZMADIA, EVA, MÜLLER, CHRISTA E., MURAKAMI, TAKASHI, ROBSON, SIMON C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930043/
https://ncbi.nlm.nih.gov/pubmed/20546740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.05.007
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