Activated protein C targets CD8(+) dendritic cells to reduce the mortality of endotoxemia in mice

Activated protein C (aPC) therapy reduces mortality in adult patients with severe sepsis. In mouse endotoxemia and sepsis models, mortality reduction requires the cell signaling function of aPC, mediated through protease-activated receptor–1 (PAR1) and endothelial protein C receptor (EPCR; also know...

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Hlavní autoři: Kerschen, Edward, Hernandez, Irene, Zogg, Mark, Jia, Shuang, Hessner, Martin J., Fernandez, Jose A., Griffin, John H., Huettner, Claudia S., Castellino, Francis J., Weiler, Hartmut
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929901/
https://ncbi.nlm.nih.gov/pubmed/20714108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42629
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