Deletion of the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Results in Impaired Insulin Secretion

The Slc30a8 gene encodes the islet-specific zinc transporter ZnT-8, which provides zinc for insulin-hexamer formation. Polymorphic variants in amino acid 325 of human ZnT-8 are associated with altered susceptibility to type 2 diabetes and ZnT-8 autoantibody epitope specificity changes in type 1 diab...

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Main Authors: Pound, Lynley D., Sarkar, Suparna, Benninger, Richard K. P., Wang, Yingda, Suwanichkul, Adisak, Shadoan, Melanie K., Printz, Richard L., Oeser, James K., Lee, Catherine E., Piston, David W., McGuinness, Owen P., Hutton, John C., Powell, David R., O’Brien, Richard M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929527/
https://ncbi.nlm.nih.gov/pubmed/19450229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090530
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