The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background

OBJECTIVE: The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes. Several groups have examined the effect of global Slc30a8 gene...

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Main Authors: Pound, Lynley D., Sarkar, Suparna A., Ustione, Alessandro, Dadi, Prasanna K., Shadoan, Melanie K., Lee, Catherine E., Walters, Jay A., Shiota, Masakazu, McGuinness, Owen P., Jacobson, David A., Piston, David W., Hutton, John C., Powell, David R., O’Brien, Richard M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400647/
https://ncbi.nlm.nih.gov/pubmed/22829903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040972
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