Modulation of Pantothenate Kinase 3 Activity by Small Molecules that Interact with the Substrate/Allosteric Regulatory Domain

Pantothenate kinase (PanK) catalyzes the rate-controlling step in coenzyme A (CoA) biosynthesis. PanK3 is stringently regulated by acetyl-CoA and uses an ordered kinetic mechanism with ATP as the leading substrate. Biochemical analysis of site-directed mutants indicates that pantothenate binds in a...

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Autori principali: Leonardi, Roberta, Zhang, Yong-Mei, Yun, Mi-Kyung, Zhou, Ruobing, Zeng, Fu-Yue, Lin, Wenwei, Cui, Jimmy, Chen, Taosheng, Rock, Charles O., White, Stephen W., Jackowski, Suzanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929395/
https://ncbi.nlm.nih.gov/pubmed/20797618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.06.006
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