Mutations in the Antifolate-Resistance-Associated Genes Dihydrofolate Reductase and Dihydropteroate Synthase in Plasmodium vivax Isolates from Malaria-Endemic Countries

Parasite dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) are known target enzymes of antifolate drugs used for the treatment and prophylaxis of persons with malaria. We sequenced the Plasmodium vivax dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) genes to e...

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Bibliographische Detailangaben
Hauptverfasser: Lu, Feng, Lim, Chae Seung, Nam, Deok Hwa, Kim, Kwonkee, Lin, Khin, Kim, Tong-Soo, Lee, Hyeong-Woo, Chen, Jun-Hu, Wang, Yue, Sattabongkot, Jetsumon, Han, Eun-Taek
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society of Tropical Medicine and Hygiene 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929037/
https://ncbi.nlm.nih.gov/pubmed/20810806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.2010.10-0004
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