Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment

BACKGROUND: To use pyrimethamine as an alternative anti-malarial drug for chloroquine-resistant malaria parasites, it was necessary to determine the enzyme's genetic variation in dihydrofolate reductase-thymidylate syntase (DHFR-TS) among Korean strains. METHODS: Genetic variation of dhfr-ts ge...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Won-Ja, Kim, Hyung-Hwan, Choi, Yien-Kyoung, Choi, Kyung-Mi, Kim, Mi-A, Kim, Jung-Yeon, Sattabongkot, Jetsumon, Sohn, Youngjoo, Kim, Hyuck, Lee, Jong-Koo, Park, Han-Sook, Lee, Hyeong-Woo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999615/
https://ncbi.nlm.nih.gov/pubmed/21087471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-9-331
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