Elastin Haploinsufficiency Results in Progressive Aortic Valve Malformation and Latent Valve Disease in a Mouse Model

RATIONALE: Elastin is a ubiquitous extracellular matrix (ECM) protein that is highly organized in heart valves and arteries. Because elastic fiber abnormalities are a central feature of degenerative valve disease, we hypothesized that elastin deficient mice would manifest viable heart valve disease....

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Detalhes bibliográficos
Main Authors: Hinton, Robert B., Adelman-Brown, Jennifer, Witt, Sandra, Krishnamurthy, Varun K., Osinska, Hanna, Sakthivel, Bhuvaneswari, James, Jeanne F., Li, Dean Y., Narmoneva, Daria A., Mecham, Robert P., Benson, D. Woodrow
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928934/
https://ncbi.nlm.nih.gov/pubmed/20576933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.221358
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