Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors

In order to fully understand protein kinase networks, new methods are needed to identify regulators and substrates of kinases, especially for weakly expressed proteins. Here we have developed a hybrid computational search algorithm that combines machine learning and expert knowledge to identify kina...

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Bibliographic Details
Main Authors: Whisenant, Thomas C., Ho, David T., Benz, Ryan W., Rogers, Jeffrey S., Kaake, Robyn M., Gordon, Elizabeth A., Huang, Lan, Baldi, Pierre, Bardwell, Lee
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928751/
https://ncbi.nlm.nih.gov/pubmed/20865152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000908
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