Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors.

In order to fully understand protein kinase networks, new methods are needed to identify regulators and substrates of kinases, especially for weakly expressed proteins. Here we have developed a hybrid computational search algorithm that combines machine learning and expert knowledge to identify kina...

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Hlavní autoři:	Thomas C Whisenant, David T Ho, Ryan W Benz, Jeffrey S Rogers, Robyn M Kaake, Elizabeth A Gordon, Lan Huang, Pierre Baldi, Lee Bardwell
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2010-08-01
Edice:	PLoS Computational Biology
On-line přístup:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000908&type=printable
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