Transduction of Human Antigen-Presenting Cells with Integrase-Defective Lentiviral Vector Enables Functional Expansion of Primed Antigen-Specific CD8(+) T Cells

Nonintegrating lentiviral vectors are being developed as a efficient and safe delivery system for both gene therapy and vaccine purposes. Several reports have demonstrated that a single immunization with integration-defective lentiviral vectors (IDLVs) delivering viral or tumor model antigens in mic...

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Bibliographic Details
Main Authors: Negri, Donatella R.M., Bona, Roberta, Michelini, Zuleika, Leone, Pasqualina, Macchia, Iole, Klotman, Mary E., Salvatore, Mirella, Cara, Andrea
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2010
Subjects:
Brief Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928704/
https://ncbi.nlm.nih.gov/pubmed/20210625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.200
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