NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

A cohort of genes associated with embryonic stem (ES) cell behaviour, including NANOG, are expressed in a number of human cancers. They form an ES-like signature we first described in glioblastoma multiforme (GBM), a highly invasive and incurable brain tumour. We have also shown that HEDGEHOG-GLI (H...

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Autores principales: Zbinden, Marie, Duquet, Arnaud, Lorente-Trigos, Aiala, Ngwabyt, Sandra-Nadia, Borges, Isabel, Ruiz i Altaba, Ariel
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928692/
https://ncbi.nlm.nih.gov/pubmed/20581802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.137
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