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Synthesis of nucleoside 5′-O-α,β-methylene-β-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase

A polymer-bound α, β-methylene-β-triphosphitylating reagent was synthesized and subjected to reactions with unprotected nucleosides, followed by oxidation, deprotection of cyanoethoxy groups, and acidic cleavage to afford nucleoside 5′-O-α, β-methylene-β-triphosphates. Among all the compounds, cytid...

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Autors principals: Ahmadibeni, Y., Dash, C., Hanley, M. J., Le Grice, S. F. J., Agarwal, H. K., Parang, K.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928660/
https://ncbi.nlm.nih.gov/pubmed/20204192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b922846b
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