Ca(2+) release from the sarcoplasmic reticulum is required for sustained TRPM4 activity in cerebral artery smooth muscle cells

The melastatin transient receptor potential (TRP) channel TRPM4 is a critical regulator of vascular smooth muscle cell membrane potential and contractility. Activation of the channel is Ca(2+)-dependent, but prolonged exposure to high (>1 μM) levels of intracellular Ca(2+) causes rapid (within ∼2...

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Hlavní autoři: Gonzales, Albert L., Amberg, Gregory C., Earley, Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2010
Témata:
Membrane Transporters, Ion Channels and Pumps
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928641/
https://ncbi.nlm.nih.gov/pubmed/20427713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00550.2009
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