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Endogenous Cytosolic Ca(2+) Buffering is Necessary for TRPM4 Activity in Cerebral Artery Smooth Muscle Cells

The melastatin transient receptor potential (TRP) channel, TRPM4, is a critical regulator of smooth muscle membrane potential and arterial tone. Activation of the channel is Ca(2+)-dependent, but prolonged exposures to high global Ca(2+) causes rapid inactivation under conventional whole-cell patch...

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Autors principals: Gonzales, Albert L., Earley, Scott
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265659/
https://ncbi.nlm.nih.gov/pubmed/22153976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2011.11.004
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