Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density

Carboxypeptidase E (CPE) is a prohormone/proneuropeptide processing enzyme, and mice bearing CPE mutations exhibit an obese and diabetic phenotype. Studies on CPE knockout (KO) mice revealed poor prohormone processing, resulting in deficiencies in peptide hormones/neuropeptides such as insulin, gona...

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Detalhes bibliográficos
Main Authors: Cawley, Niamh X., Yanik, Tulin, Woronowicz, Alicja, Chang, Weizhong, Marini, Joan C., Loh, Y. Peng
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928512/
https://ncbi.nlm.nih.gov/pubmed/20460579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00516.2009
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