Distinct Patterns of DNA Damage Response and Apoptosis Correlate with Jak/Stat and PI3Kinase Response Profiles in Human Acute Myelogenous Leukemia

BACKGROUND: Single cell network profiling (SCNP) utilizing flow cytometry measures alterations in intracellular signaling responses. Here SCNP was used to characterize Acute Myeloid Leukemia (AML) disease subtypes based on survival, DNA damage response and apoptosis pathways. METHODOLOGY AND PRINCIP...

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Hoofdauteurs: Rosen, David B., Putta, Santosh, Covey, Todd, Huang, Ying-Wen, Nolan, Garry P., Cesano, Alessandra, Minden, Mark D., Fantl, Wendy J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2010
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928279/
https://ncbi.nlm.nih.gov/pubmed/20811632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012405
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