Distinct Patterns of DNA Damage Response and Apoptosis Correlate with Jak/Stat and PI3Kinase Response Profiles in Human Acute Myelogenous Leukemia

BACKGROUND: Single cell network profiling (SCNP) utilizing flow cytometry measures alterations in intracellular signaling responses. Here SCNP was used to characterize Acute Myeloid Leukemia (AML) disease subtypes based on survival, DNA damage response and apoptosis pathways. METHODOLOGY AND PRINCIP...

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Detalhes bibliográficos
Main Authors: Rosen, David B., Putta, Santosh, Covey, Todd, Huang, Ying-Wen, Nolan, Garry P., Cesano, Alessandra, Minden, Mark D., Fantl, Wendy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928279/
https://ncbi.nlm.nih.gov/pubmed/20811632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012405
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