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Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability
BACKGROUND: Microsatellite instability (MSI) occurs in 15% of colorectal cancers (CRC). The genetic targets for mutation in the MSI phenotype include somatic mutations in the transforming growth factor beta receptor typeII (TGFbetaRII), BAX, hMSH3 and hMSH6. It is not clear how mutations of these ge...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2927997/ https://ncbi.nlm.nih.gov/pubmed/20565851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-303 |
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