Ablation of 4E-BP1/2 Prevents Hyperglycemia-Mediated Induction of VEGF Expression in the Rodent Retina and in Müller Cells in Culture

OBJECTIVE: Vascular endothelial growth factor (VEGF) contributes to diabetic retinopathy, but control of its expression is not well understood. Here, we tested the hypothesis that hyperglycemia mediates induction of VEGF expression in a eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP)...

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Detalhes bibliográficos
Main Authors: Schrufer, Tabitha L., Antonetti, David A., Sonenberg, Nahum, Kimball, Scot R., Gardner, Thomas W., Jefferson, Leonard S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927931/
https://ncbi.nlm.nih.gov/pubmed/20547975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0148
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