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The Use of Family Relationships and Linkage Disequilibrium to Impute Phase and Missing Genotypes in Up to Whole-Genome Sequence Density Genotypic Data

A novel method, called linkage disequilibrium multilocus iterative peeling (LDMIP), for the imputation of phase and missing genotypes is developed. LDMIP performs an iterative peeling step for every locus, which accounts for the family data, and uses a forward–backward algorithm to accumulate inform...

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Autores principales: Meuwissen, Theo, Goddard, Mike
Formato: Artigo
Lenguaje:Inglês
Publicado: Genetics Society of America 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927768/
https://ncbi.nlm.nih.gov/pubmed/20479147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.113936
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