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Accounting for Decay of Linkage Disequilibrium in Haplotype Inference and Missing-Data Imputation

Although many algorithms exist for estimating haplotypes from genotype data, none of them take full account of both the decay of linkage disequilibrium (LD) with distance and the order and spacing of genotyped markers. Here, we describe an algorithm that does take these factors into account, using a...

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Bibliographic Details
Main Authors: Stephens, Matthew, Scheet, Paul
Format: Artigo
Language:Inglês
Published: The American Society of Human Genetics 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196397/
https://ncbi.nlm.nih.gov/pubmed/15700229
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