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Action of the Chaperonin GroEL/ES on a Non-Native Substrate Observed with Single-Molecule FRET

The double-ring-shaped chaperonin GroEL binds a wide range of non-native polypeptides within its central cavity and, together with its cofactor GroES, assists their folding in an ATP-dependent manner. While the conformational cycle of GroEL/ES has been extensively studied, little is known about how...

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Detalhes bibliográficos
Main Authors: Kim, So Yeon, Miller, Erik J., Frydman, Judith, Moerner, W. E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927214/
https://ncbi.nlm.nih.gov/pubmed/20600107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.06.050
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