Introduction of an N-Glycan Sequon Into HEXA Enhances Human β-Hexosaminidase Cellular Uptake in a Model of Sandhoff Disease

Human lysosomal β-hexosaminidase A is a heterodimer composed of α- and β-subunits encoded by HEXA and HEXB, respectively. We genetically introduced an additional N-glycosylation sequon into HEXA, which caused amino acid substitutions (S51 to N and A53 to T) at homologous positions to N84 and T86 in...

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Autors principals: Matsuoka, Kazuhiko, Tsuji, Daisuke, Aikawa, Sei-ichi, Matsuzawa, Fumiko, Sakuraba, Hitoshi, Itoh, Kohji
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927063/
https://ncbi.nlm.nih.gov/pubmed/20571546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.113
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