Enhancement by Uridine Diphosphate of Macrophage Inflammatory Protein-1 Alpha Production in Microglia Derived from Sandhoff Disease Model Mice

Sandhoff disease (SD) is a lysosomal β-hexosaminidase (Hex) deficiency involving excessive accumulation of undegraded substrates, including GM2 ganglioside, and progressive neurodegeneration. Macrophage inflammatory protein-1α (MIP-1α) is a crucial factor for microglia-mediated neuroinflammation in...

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Publicado en:JIMD Rep
Autores principales: Kawashita, Eri, Tsuji, Daisuke, Kanno, Yosuke, Tsuchida, Kaho, Itoh, Kohji
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059200/
https://ncbi.nlm.nih.gov/pubmed/26545879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/8904_2015_496
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