Production of Recombinant β-Hexosaminidase A, a Potential Enzyme for Replacement Therapy for Tay-Sachs and Sandhoff Diseases, in the Methylotrophic Yeast Ogataea minuta

Human β-hexosaminidase A (HexA) is a heterodimeric glycoprotein composed of α- and β-subunits that degrades GM2 gangliosides in lysosomes. GM2 gangliosidosis is a lysosomal storage disease in which an inherited deficiency of HexA causes the accumulation of GM2 gangliosides. In order to prepare a lar...

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Détails bibliographiques
Auteurs principaux: Akeboshi, Hiromi, Chiba, Yasunori, Kasahara, Yoshiko, Takashiba, Minako, Takaoka, Yuki, Ohsawa, Mai, Tajima, Youichi, Kawashima, Ikuo, Tsuji, Daisuke, Itoh, Kohji, Sakuraba, Hitoshi, Jigami, Yoshifumi
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2007
Sujets:
Physiology and Biotechnology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951009/
https://ncbi.nlm.nih.gov/pubmed/17557860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00463-07
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