Disrupting 5-HT(2A) Receptor/PDZ Protein Interactions Reduces Hyperalgesia and Enhances SSRI Efficacy in Neuropathic Pain

Antidepressants are one of the first-line treatments for neuropathic pain. Despite the influence of serotonin (5-hydroxytryptamine, 5-HT) in pain modulation, selective serotonin reuptake inhibitors (SSRIs) are less effective than tricyclic antidepressants. Here, we show, in diabetic neuropathic rats...

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Bibliografiske detaljer
Main Authors: Pichon, Xavier, Wattiez, Anne S, Becamel, Carine, Ehrlich, Ingrid, Bockaert, Joel, Eschalier, Alain, Marin, Philippe, Courteix, Christine
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927054/
https://ncbi.nlm.nih.gov/pubmed/20531396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.101
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