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Constitutively active mutants of 5-HT(4) receptors are they in unique active states?

Somatic mutations leading to constitutively active G-protein coupled receptors (GPCRs) are responsible for certain human diseases. A consistent structural description of the molecular change underlying the conversion of GPCRs from an inactive R state to an active R* state is lacking. Here, we show t...

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Detalhes bibliográficos
Main Authors: Claeysen, Sylvie, Sebben, Michèle, Bécamel, Carine, Parmentier, Marie-Laure, Dumuis, Aline, Bockaert, Joël
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083800/
https://ncbi.nlm.nih.gov/pubmed/11252726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve003
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