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Constitutively active mutants of 5-HT(4) receptors are they in unique active states?
Somatic mutations leading to constitutively active G-protein coupled receptors (GPCRs) are responsible for certain human diseases. A consistent structural description of the molecular change underlying the conversion of GPCRs from an inactive R state to an active R* state is lacking. Here, we show t...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083800/ https://ncbi.nlm.nih.gov/pubmed/11252726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve003 |
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