5-HT(4) Receptors Constitutively Promote the Non-Amyloidogenic Pathway of APP Cleavage and Interact with ADAM10

[Image: see text] In addition to the amyloidogenic pathway, amyloid precursor protein (APP) can be cleaved by α-secretases, producing soluble and neuroprotective APP alpha (sAPPα) (nonamyloidogenic pathway) and thus preventing the generation of pathogenic amyloid-β. However, the mechanisms regulatin...

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Bibliografiske detaljer
Main Authors: Cochet, Maud, Donneger, Romain, Cassier, Elisabeth, Gaven, Florence, Lichtenthaler, Stefan F., Marin, Philippe, Bockaert, Joël, Dumuis, Aline, Claeysen, Sylvie
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547471/
https://ncbi.nlm.nih.gov/pubmed/23336052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300095t
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