The Cancer-related Runx2 Protein Enhances Cell Growth and Responses to Androgen and TGFβ in Prostate Cancer Cells

Prostate cancer cells often metastasize to bone where osteolytic lesions are formed. Runx2 is an essential transcription factor for bone formation and suppresses cell growth in normal osteoblasts, but may function as an oncogenic factor in solid tumors (e.g., breast, prostate). Here, we addressed wh...

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Auteurs principaux: van der Deen, Margaretha, Akech, Jackie, Wang, Tao, FitzGerald, Thomas J., Altieri, Dario C., Languino, Lucia R., Lian, Jane B., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925394/
https://ncbi.nlm.nih.gov/pubmed/20082326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22463
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