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Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases

NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII, is a DNA glycosylase that repairs ring-fragmented purines, saturated pyrimidines and several oxidative lesions like 5-hydroxyuracil, 5-hydroxycytosine etc. Previous studies from our laboratory have shown that Werner Syndrome protein...

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Autores principales: Popuri, Venkateswarlu, Croteau, Deborah L., Bohr, Vilhelm A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925176/
https://ncbi.nlm.nih.gov/pubmed/20346739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.02.012
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