Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing

We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during the critical first weeks of infection. Previous studies suggested that a single...

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Main Authors: Fischer, Will, Ganusov, Vitaly V., Giorgi, Elena E., Hraber, Peter T., Keele, Brandon F., Leitner, Thomas, Han, Cliff S., Gleasner, Cheryl D., Green, Lance, Lo, Chien-Chi, Nag, Ambarish, Wallstrom, Timothy C., Wang, Shuyi, McMichael, Andrew J., Haynes, Barton F., Hahn, Beatrice H., Perelson, Alan S., Borrow, Persephone, Shaw, George M., Bhattacharya, Tanmoy, Korber, Bette T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924888/
https://ncbi.nlm.nih.gov/pubmed/20808830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012303
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