Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3’-UTR microRNA

Targeting tumor-related overexpression of anti-apoptotic Bcl2 protein by RNAi has been suggested as a potential treatment for cancer. However, the stability of RNAi and its delivery are still major obstacles to the clinical testing of Bcl2 RNAi. Here we explore a novel strategy of expressing a synth...

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Autori principali: Zhang, Jianjun, Huang, Shenglin, Zhang, He, Wang, Haibo, Guo, Haiyan, Qian, Guanxiang, Fan, Xianqun, Lu, Jian, Hoffman, Andrew R., Hu, Ji-Fan, Ge, Shengfang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924819/
https://ncbi.nlm.nih.gov/pubmed/19676053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24821
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