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Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3’-UTR microRNA
Targeting tumor-related overexpression of anti-apoptotic Bcl2 protein by RNAi has been suggested as a potential treatment for cancer. However, the stability of RNAi and its delivery are still major obstacles to the clinical testing of Bcl2 RNAi. Here we explore a novel strategy of expressing a synth...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924819/ https://ncbi.nlm.nih.gov/pubmed/19676053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24821 |
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