TGF-β Utilizes SMAD3 to Inhibit CD16-Mediated IFN-γ Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells

TGF-β can be a potent suppressor of lymphocyte effector cell functions and can mediate these effects via distinct molecular pathways. The role of TGF-β in regulating CD16-mediated NK cell IFN-γ production and antibody-dependent cellular cytotoxicity (ADCC) is unclear, as are the signaling pathways t...

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Bibliographic Details
Main Authors:	Trotta, Rossana, Col, Jessica Dal, Yu, Jianhua, Ciarlariello, David, Thomas, Brittany, Zhang, Xiaoli, Allard, Jeffrey, Wei, Min, Mao, Hsiaoyin, Byrd, John C., Perrotti, Danilo, Caligiuri, Michael A.
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2924753/ https://ncbi.nlm.nih.gov/pubmed/18768831
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TGF-β Utilizes SMAD3 to Inhibit CD16-Mediated IFN-γ Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells

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