SMAD4 promotes TGF-β–independent NK cell homeostasis and maturation and antitumor immunity

SMAD4 is the only common SMAD in TGF-β signaling that usually impedes immune cell activation in the tumor microenvironment. However, we demonstrated here that selective deletion of Smad4 in NK cells actually led to dramatically reduced tumor cell rejection and augmented tumor cell metastases, reduce...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Wang, Youwei, Chu, Jianhong, Yi, Ping, Dong, Wejuan, Saultz, Jennifer, Wang, Yufeng, Wang, Hongwei, Scoville, Steven, Zhang, Jianying, Wu, Lai-Chu, Deng, Youcai, He, Xiaoming, Mundy-Bosse, Bethany, Freud, Aharon G., Wang, Li-Shu, Caligiuri, Michael A., Yu, Jianhua
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205382/
https://ncbi.nlm.nih.gov/pubmed/30183689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121227
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