Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease

OBJECTIVE: Prostacyclin and thromboxane mediate opposing cardiovascular effects through their receptors, the IP and TP, respectively. Individuals heterozygous for an IP variant, IP(R212C), displayed exaggerated loss of platelet IP responsiveness and accelerated cardiovascular disease. We examined as...

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Bibliographic Details
Main Authors: Ibrahim, Salam, Tetruashvily, Mazell, Frey, Alex J, Wilson, Stephen J, Stitham, Jeremiah, Hwa, John, Smyth, Emer M
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924460/
https://ncbi.nlm.nih.gov/pubmed/20522800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.208900
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