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Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease
OBJECTIVE: Prostacyclin and thromboxane mediate opposing cardiovascular effects through their receptors, the IP and TP, respectively. Individuals heterozygous for an IP variant, IP(R212C), displayed exaggerated loss of platelet IP responsiveness and accelerated cardiovascular disease. We examined as...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924460/ https://ncbi.nlm.nih.gov/pubmed/20522800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.208900 |
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