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The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, β-Arrestin-1-dependent ERK Phosphorylation

Metabotropic glutamate receptor 1 (mGlu1) is a G protein-coupled receptor that enhances the hydrolysis of membrane phosphoinositides. In addition to its role in synaptic transmission and plasticity, mGlu1 has been shown to be involved in neuroprotection and neurodegeneration. In this capacity, we ha...

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Detalhes bibliográficos
Main Authors: Emery, Andrew C., Pshenichkin, Sergey, Takoudjou, Guy Rodrigue, Grajkowska, Ewa, Wolfe, Barry B., Wroblewski, Jarda T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924003/
https://ncbi.nlm.nih.gov/pubmed/20566651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.139899
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