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Cyclothiazide Selectively Inhibits mGluR1 Receptors Interacting with a Common Allosteric Site for Non-competitive Antagonists
Metabotropic glutamate receptors mGluR1 and mGluR5 stimulate phospholipase C, leading to an increased inositol triphosphate level and to Ca(2+) release from intracellular stores. Cyclothiazide (CTZ), known as a blocker of AMPA receptor desensitization, produced a non-competitive inhibition of [Ca(2+...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1876747/ https://ncbi.nlm.nih.gov/pubmed/17095021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2006.09.018 |
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