Laddar...
Discovery and SAR of Novel mGluR5 Non-Competitive Antagonists Not Based on an MPEP Chemotype
This Letter describes the discovery and SAR of three novel series of mGluR5 non-competitive antagonists/negative allosteric modulators (NAMs) not based on manipulation of an MPEP/MTEP chemotype. This work demonstrates fundamentally new mGluR5 NAM chemotypes with submicromolar potencies, and the firs...
Sparad:
| Huvudupphovsmän: | , , , , , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2009
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177605/ https://ncbi.nlm.nih.gov/pubmed/19443219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.04.110 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|